The Code Breaker is the CRISPR chronicle you need to read

3d render of DNA spirals.

3d render of DNA spirals. (credit: Image courtesy of NIST)

According to Walter Isaacson, three great technology revolutions have shaped the modern world, based on three fundamental kernels of human existence: the atom, the bit, and the gene. Having explored the physics revolution through the eyes of Einstein, and the digital revolution via Apple’s supreme leader, Steve Jobs, the best-selling biographer thought it was time to turn to DNA. It’s no surprise then, that he chose Jennifer Doudna, the co-discoverer of the Crispr gene-editing technology, to carry the tale of how the human species seized control of its own evolutionary destiny..

Isaacson’s latest book, The Code Breaker, breathlessly follows Doudna from a childhood spent trekking through the wilds of Hawaii to her pioneering work harnessing a bacterial defense system to rewrite the code of life—and the bitter patent battle that ensued—and ultimately winning the ultimate credit, the Nobel Prize. Based on more than five years of reporting from the front lines of the DNA-hacking wars, the book is an immersive deep dive into the fascinating science of gene editing and the personal dramas playing out behind the discoveries. Even if you think you know the story of Crispr, you don’t know it the way Isaacson does.

He spoke to WIRED from his home in New Orleans, where he is now a professor of history at Tulane University. This interview has been edited for length and clarity.

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